Which Type Of Enzyme Can Repair Dna Damage In Eukaryotes?
MCQ on Deoxyribonucleic acid Repair Mechanism
(Molecular Biology MCQ – 01)
one. Which of the following Dna repair machinery is known as the 'cut and patch mechanism'?
a. Photoreactivation
b. Nucleotide excision repair
c. Base excision repair
d. Mismatch repair
two. Dna helicase enzyme involved in base excision repair mechanism is______.
a. DNA helicase I
b. Deoxyribonucleic acid helicase II
c. Deoxyribonucleic acid helicase III
d. Dna helicase IV
3. In mismatch repair mechanism, which of the following protein recognize Dna mismatches in the genomic DNA?
a. MutH
b. MutS
c. MutL
d. UvrD
4. The main divergence between nucleotide excision repair (NER) and base excision repair (BER) is:
a. In NER double strand breaks are repaired where as in BER single strand breaks repaired
b. NER is a light dependent reaction whereas BER is light independent procedure
c. In NER phosphodiester backbone is first broken where as in BER phosphodiester backbone is cleaved later
d. All of these
five. Which enzyme is responsible for photoreactivation of DNA:
a. Photoligase
b. Photoreductase
c. Photo-oxidase
d. Photolyase
vi. Which of the following enzyme(s) is involved base excision repair?
a. Dna glycosylase
b. AP endonuclease
c. AP exonuclease
d. (a), (b) and (c)
e. Both (a) and (b)
7. Xeroderma pigmentosum in man is associated with a mutation in
a. Photoreactivation
b. Nucleotide excision repair
c. Base of operations excision repair
d. Mismatch repair
8. Which of the following factor is NOT involved in mismatch repair system in bacteria?
a. MutS
b. MutA
c. MutL
d. UvrD
9. In eukaryotes, the mismatch repair mechanism is initiated and directed by_____.
a. Methylated Deoxyribonucleic acid strand
b. Acetylated Dna strand
c. Strand specific nicks
d. Double strand breaks
10. In nucleotide excision repair mechanism which of the post-obit proteins first recognize Deoxyribonucleic acid lesion?
a. UvrA
b. UvrB
c. UvrC
d. UvrD
eleven. The 2 chromophores present in photolyase enzyme are:
a. NAD and FAD
b. FAD and Folate
c. FADH and Folate –
d. FAD – and Folate
12. Which of the post-obit statement is true regarding the nucleotide excision repair (NER) mechanism?
a. NER mechanism is nowadays but in eukaryotes
b. NER present simply in prokaryotes
c. NER Present in both prokaryotes and eukaryotes but the exact mechanisms varies
d. NER Present in both prokaryotes and eukaryotes with similar molecular mechanism in both
13. Photolyase enzyme involved in the photoreactivation tin remove ______.
a. UV induced double strand breaks
b. UV induced thymine dimers
c. Mismatches in Deoxyribonucleic acid
d. Unmarried strand breaks in Deoxyribonucleic acid
14. Dna polymerase enzyme involved in base excision repair machinery is ______.
a. Pol-α
b. Politico-β
c. Pol-γ
d. Political leader-δ
xv. Deoxyribonucleic acid polymerase enzyme involved in mismatch repair system of E. coli is ______.
a. Deoxyribonucleic acid Pol-I
b. DNA Pol-Ii
c. DNA Pol-III
d. DNA Pol-β
xvi. In NER machinery, which of the post-obit protein processes the helicase activeness?
a. UvrA
b. UvrB
c. UvrC
d. UvrD
17. The catalytic activeness of photolyase enzyme in the bacterial cells is activated by _____.
a. UV low-cal
b. IR lite
c. Visible light near blue region
d. Visible calorie-free about cerise region
xviii. In NER (nucleotide excision repair) mechanism, the incision at the 3' position of the lesion is done by______.
a. Uvr A
b. UvrB
c. UvrC
d. UvrD
19. In mismatch repair machinery, the endonuclease activity which cut the nascent DNA strand is washed by:
a. MutH
b. MutL
c. MutS
d. UvrD
twenty. The activeness of AP endonuclease is involved in ________.
a. Base excision repair
b. Nucleotide excision repair
c. Mismatch repair
d. Double strand break repair
21. Which of the post-obit argument is correct?
a. Photoreactivation is absent in human being
b. Photoreactivation is present in all organism
c. Photoreactivation nowadays only in plants and animals
d. Photoreactivation is present but in bacteria
22. The enzyme photolyase repair the thymine dimer in the Deoxyribonucleic acid by __________ machinery.
a. Oxidation machinery
b. Free radical mechanism
c. Direct bond breaking
d. Adduct formation
23. In E. coli, inactivation of cellular Deoxyribonucleic acid methylase enzyme causes severe mutation in the genomic DNA. Which of the following Deoxyribonucleic acid repair mechanism would be most probably inhibited?
a. Double strand break repair
b. Mismatch repair
c. Base Excision Repair
d. Nucleotide Excision Repair
24. The function of UvrC in NER mechanism is_________.
a. To place the lesion in the Deoxyribonucleic acid
b. Helicase action to unwind the Dna
c. Catalyze the incision at the 3' end of the lesion
d. Catalyze the incision at the five' side of the lesion
25. Get-go Deoxyribonucleic acid glycosylase enzyme discovered is ___________.
a. Uracil Dna glycosylase
b. Thymine Dna glycosylase
c. Adenine DNA glycosylase
d. Methyl Adenine Glycosylase
More Molecular Biology MCQs
DNA Repair Mechanisms MCQ 019: Answer Fundamental
i. Ans. (b). Nucleotide excision repair
2. Ans. (c). Dna helicase III
3. Ans. (b). MutS
4. Ans. (c). In NER phosphodiester backbone is showtime cleaved where as in BER phosphodiester backbone is cleaved later
5. Ans. (d). Photolyase
6. Ans. (e). Both (a) and (b)
7. Ans. (b). Nucleotide excision repair
8. Ans. (b). MutA
9. Ans. (c). Strand specific nicks
10. Ans. (a). UvrA
xi. Ans. (d). FAD – and Folate
12. Ans. (c). NER present in both prokaryotes and eukaryotes merely the verbal mechanism varies
xiii. Ans. (b). UV induced thymine dimer
14. Ans. (b). Politician-β
15. Ans. (c). DNA Pol-III
16. Ans. (d). UvrD
17. Ans. (c). Visible light most bluish region
eighteen. Ans. (b). UvrB
19. Ans. (a). MutH
20. Ans. (a). Base excision repair
21. Ans. (a). Photoreactivation is nowadays in human
22. Ans. (b). Free radical mechanism
23. Ans. (b). Mismatch repair
24. Ans. (d). Catalyze the incision at 5' side of the lesion
25. Ans. (a). Uracil DNA glycosylase
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